Anticarcinogenic and antilipidperoxidative effects of Tephrosia purpurea (Linn.) Pers. in 7, 12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinoma

Objectives: To investigate the chemopreventive potential and antilipidperoxidative efDepartment of Biochemistry, fects of ethanolic root extract of Tephrosia purpurea (Linn.) Pers. (TpEt) on 7,12Faculty of Science, dimethylbenz(a)anthracene (DMBA)induced hamster buccal pouch carcinoma. Annamalai University Materials and Methods: Oral squamous cell carcinoma was developed in the buccal Annamalainagar 608 002, pouch of Syrian golden hamsters, by painting with 0.5% DMBA in liquid paraffin, thrice a Tamil Nadu. India week, for 14 weeks. The tumor incidence, volume, and burden were determined. Oral administration of TpEt at a dose of 300 mg/kg, b.w., to DMBA (on alternate days for Received: 11.1.2006 14 weeks)painted animals significantly prevented the incidence, volume and burden of Revised: 21.3.2006 the tumor. Accepted: 22.3.2006 Results: TpEt showed potent antilipidperoxidative effect, as well as enhanced the antioxiCorrespondence to: dant status in DMBApainted animals. S. Manoharan Conclusion: TpEt has potent chemopreventive efficacy and significant antilipidperoxidative E-mail : [email protected] effect, in DMBA-induced oral carcinogenesis. Further studies are needed to isolate and characterize the bioactive principle.